12

Infection Control,
Aseptic Technique,
and Cleanroom
Facilities

Learning Objectives

1Explain the role of pathogenic organisms in causing disease and distinguish between bacteria, viruses, fungi, and protozoa. (Section 12.1)

2Discuss the dangers of antimicrobial resistance, superbugs, and healthcare-associated infections. (Section 12.1)

3Identify common modes of contamination and the preventive measures. (Section 12.2)

4Explain the role of CDC guidelines (including the universal precautions), the Infection Control Committee, and USP Chapter <797>. (Section 12.3)

5Discuss the advantages and disadvantages of various forms of sterilization. (Section 12.4)

6State the preparatory processes that must be completed prior to assembling compounded sterile preparations (CSPs). (Section 12.5)

7Describe the different types of sterile products. (Section 12.5)

8State the training requirements of becoming a sterile compounding technician. (Section 12.5)

9Paraphrase the layout of a cleanroom and its ISO air environment standards, and the different levels of air quality controls, including primary and secondary engineering controls. (Section 12.6)

10Describe methods of aeseptic technique, including garbing and washing. (Section 12.7)

11Describe basic cleanroom quality assurance and control procedures. (Section 12.7)

12Identify the role and function of equipment used in sterile compounding, including syringes, needles, intravenous sets (and their components), and filters. (Section 12.8)

ASHP/ACPE Accreditation Standards

To view the ASHP/ACPE Accreditation Standards addressed in this chapter, refer to Appendix B.

For pharmacy technicians working in the hospital setting, a good understanding of infection control procedures is critical. Patients with severe diseases often have compromised immune systems and are more susceptible to serious, and sometimes life-threatening, infections. In addition, microorganisms have a greater ability to adapt and become resistant to potent antibiotics in a hospital setting. In light of these facts, it is important for you to understand how infection spreads and how hospitals can employ special infection control practices to limit the possibility of contamination. Any breach in protocol increases the risk for serious infections for patients and healthcare workers.

Many drugs ordered for patients in hospitals and other healthcare settings are administered directly into veins, so they must be specially compounded in a strictly controlled environment that is as germ-free as possible. Though a technician (and pharmacist) needs special training to work in one of these compounding areas, it is essential that every pharmacy technician understands an overview of USP Chapter <797> and the goals, key concepts, cleanroom layout, and aseptic technique, in addition to the intravenous (IV) supplies and equipment for sterile compounding. Many of the concepts and supplies also apply in sterile hazardous compounding. Having this context will prepare you to understand the overview of the processes and procedures of sterile and hazardous compounding addressed in the next chapter.